11 Best Hair Growth Serums to Address Thinning Hair

Table Of Content

• Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review
• About the Reviewer
• Will Dutasteride Cause the Same Side Effects as Finasteride?
• Healthy Eating
• What are the potential risks of using dutasteride to treat hair loss?
• Best for Damaged Hair: Kérastase Genesis Fortifiant Hair Serum

Alopecia areata is an autoimmune disease that causes hair to fall out in nickel- or quarter-size patches. Several serious diseases also attack the hair follicle, says Robert Brodell, a dermatologist at the University of Mississippi Medical Center. While alopecia doesn’t typically affect your physical health, the emotional and psychological distress it can cause are very real.

Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review

You should see your doctor if this bothers you and if you notice lumps in the breast or discharge from your nipple. Dutasteride has been shown to reduce sperm count, semen volume and the movement of sperm, which could affect male fertility. Dutasteride is also not recommended for use by men with serious liver disease. In fact, some brands are now making dutasteride capsules, shampoos, and topical solutions available directly to customers.

Boomer health: study of the most effective hair loss remedies - Palm Beach Post

Boomer health: study of the most effective hair loss remedies.

Posted: Tue, 15 Feb 2022 08:00:00 GMT [source]

About the Reviewer

In some people, DHT binds to their hair follicles, causing shrinkage and eventual hair loss. Dutasteride (0.5 mg/day) is approved for treatment of AGA in South Korea, Japan, and Taiwan11,12,13. However, efficacy and safety data for dutasteride is largely derived from short-term clinical trials and post-marketing surveillance studies6,7,8,14,15,16. Long-term, real-world evidence for the effectiveness of dutasteride is limited. Dutasteride seems to provide a better efficacy compared with finasteride in treating AGA.

Will Dutasteride Cause the Same Side Effects as Finasteride?

As with finasteride, dutasteride should not be taken or handled by a woman who is pregnant or who may become pregnant because of the drug’s potential to cause abnormal development of a fetus. The side effects of dutasteride are similar to those reported for finasteride. Dutasteride is a 5-alpha reductase inhibitor somewhat similar to finasteride; however, dutasteride blocks both 5AR l and 5AR ll, whereas finasteride is only a 5AR ll inhibitor. In addition, its half-life in the serum is much longer than for finasteride- 5 weeks for dutasteride compared to 6-8 hrs for finasteride.

Ultimately there is not a best time of day to take dutasteride for hair loss. Choose a time of day that works best for you whether it be in the morning, evening, or night time, and make sure to consistently take it at that time in order to maximize the effectiveness of the medication. Dutasteride should be taken as a whole capsule daily on a regular basis for at least 3-6 months before seeing any benefits. Be sure to store dutasteride at room temperature, away from heat, moisture, and light.

#VisualAbstract: Dutasteride 0.5mg daily has the highest probability of being the most efficacious treatment for male ... - 2 Minute Medicine

#VisualAbstract: Dutasteride 0.5mg daily has the highest probability of being the most efficacious treatment for male ....

Posted: Thu, 10 Feb 2022 08:00:00 GMT [source]

What are the potential risks of using dutasteride to treat hair loss?

Medical News Today follows a strict product selection and vetting process. Please note that the writer of this article has not tried these products. All information presented is purely research-based and correct at the time of publication. Dr Amy Revene M.B.B.S. graduated from the University of Sharjah in the United Arab Emirates.

Best with Minoxidil: Hers Women’s Minoxidil 2% Topical Solution

The IR of improvement for treatments were compared using IR ratios (IRRs) derived from Poisson models in univariate and multivariate analyses. Dr. Green incorporates the latest topical and oral treatments for hair loss, including oral Dutasteride, oral Minoxidil, Spirinolactone, and Finasteride (Propecia). She has specially compounded hair serums to replace and thicken thinning hair and hair loss. As an international expert in hair loss and Platelet Rich Plasma (PRP) for alopecia, Dr. Green is always looking for ways to improve the treatment of hair loss for her patients. Dr. Michele Green is an internationally renowned dermatologist that is consistently voted as one of New York’s best dermatologists by Castle Connolly, Super Doctors, The New York Times and New York Magazine. Dutasteride has gained significant attention in recent years as a potential treatment for hair loss.

A 2021 review of 15 studies — including several large randomized control trials that are the gold standard for medical research — found that laser therapy increased hair count in both men and women. You can either purchase over-the-counter laser devices to use at home or receive the treatments from a provider. In another 2017 study, researchers reviewed the effects of dutasteride and finasteride in men with androgenetic alopecia. They found that dutasteride was more effective, but its adverse effects were similar to finasteride. However, this study used a small sample size and had a short duration, so more research is needed to confirm its results in the wider population. Minoxodil may be more effective if a person combines it with other hair loss treatments.

Dutasteride is normally prescribed off-label for hair loss in a dosage of one 0.5mg capsule taken once daily. This may be a singular treatment consisting of just the Dutasteride, or sometimes the Dutasteride 0.5mg capsule will also be paired with another prostate medication, Tamsulosin. When you are using Dutasteride for an enlarged prostate, the doctor will normally prescribe the 0.5mg capsule to be taken once every day.

Dutasteride works as a DHT (dihydrotestosterone) blocker, lowering DHT levels in the body. When DHT binds to the hair follicles, it causes thinner hair and hair loss. With respect to intralesional therapy with dutasteride, some considerations should be highlighted. There are no reports regarding sexual side effects in the medical literature; thus, this does not appear to be a serious concern [13]. Furthermore, some other side effects such as patchy hair loss, cicatricial alopecia, and multifocal scalp abscess described in the medical literature are merely based on case reports [7]. Androgenetic alopecia (AGA) is the most common cause of hair loss affecting both men and women [1].

Even though the drug was first made to treat a prostate that was too big, it has been shown to be effective in both preventing and treating male pattern baldness. Minoxidil is another popular hair loss treatment that has been around for decades. Unlike dutasteride and finasteride, which are both oral medications, minoxidil is a topical treatment that is applied directly to the scalp. Green says that the two primary medications that are currently FDA-approved for treating hair loss are finasteride and minoxidil.

This means that Dutasteride helps block both type 1 and type 2 versions of the 5-alpha reductase enzyme. It is available combined with ethynyl estradiol as an oral contraceptive in many countries but is not approved in the United States. Other reported side effects of finasteride include decreased libido, gynecomastia, testicular pain, and depression. Ketoconazole is an antifungal medication, often seen in topical treatments like shampoos.

If you’re specifically interested in anti-androgens, consider other topical anti-androgenic drugs that are in clinical trials, like Kintor Pharma’s pyrilutamide (KX-826). Cosmo Pharma’s high-strength clascoterone (best known by its brand name, Breezula®) is another topical anti-androgen. Investigators are currently recruiting for Breezula® phase III clinical trials. Dutasteride is a reasonable alternative to finasteride but some doctors are reluctant to use it because of its long half-life in the body. If wanting to use a 5AR inhibitor while starting a family, finasteride is the better choice.

The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Due to these findings, a warning is often present on the prescribing information that comes with these pills. However, more recent research suggests that there isn’t an increased risk of prostate cancer in those taking DHT blockers. Risk of bias assessment of the included studies according to the Cochrane guidelines.

Dutasteride is an androgen blocker that’s approved to treat male pattern hair loss (also known as androgenetic alopecia)  in Japan and South Korea. It’s also FDA-approved for the treatment of benign prostate hyperplasia — commonly known as an enlarged prostate. This oral medication is generally thought of as a stronger version of finasteride, so it’s sometimes used off-label to treat androgenic alopecia. The rate of AEs overall was low in both treatment groups, although the calculated IR of AEs were numerically higher among finasteride-treated patients compared with dutasteride-treated patients. In the present study, skin conditions were the most frequently reported AE, and mostly occurred among finasteride-treated patients. The relatively high frequency (compared with the incidence of other AEs) observed in both treatment groups may be attributable to patient treatment by dermatologists.

The occurrence of skin conditions should be monitored in future studies as they have been reported in a post-marketing surveillance study conducted in South Korea (2.5% among dutasteride-treated patients)15. AEs, relating to sexual dysfunction, were equivalent between treatment groups. Two separate meta-analyses show altered libido occurred in 6.7%~18.9% and 1.2%~6.7% of finasteride-treated patients; and 4.8%~22.8% and 1.5%~11.8% of dutasteride-treated patients18,22.